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Why Prebiotics & Probiotics together?

Why Prebiotics & Probiotics together?

The role of the intestine is not limited to the assimilation of nutrients and the elimination of waste, but it extends to the protection of the whole body. Indeed, it provides an effective preservation against bacteria, viruses, toxic and allergens in the intestinal lumen, through three defensive lines: the intestinal flora, intestinal epithelium, and the intestinal immune system.

Our intestines produce 70 to 85% of the immune cells of the organism and host 100 000 billion bacteria from 400 different species which compose the intestinal flora.

Among these bacteria, most are harmless or beneficial for the body. Under normal circumstances, other, potentially pathogenic, are too few to have an adverse effect. Indeed, by producing lactic acid, the “good” bacteria make the intestinal environment unfavorable to the development of pathogenic bacteria.

The bacteria of the intestinal flora feed on derived food unused by the body (fibers, cartilage, etc.) and play an important role:
– Digestion: The flora completes the food digestion by the fermentation process. It also participates to the digestive motility, in other words, the intestinal transit.
– Assimilation of nutrients.
– Elimination of waste: cholesterol uptake, elimination of toxic as ammonia, nitrites, etc.
– Barrier against infection: the bacteria of the intestinal flora stimulate macrophages and lymphocytes; these cells play a major role in the general immunity of our body.
But, any aggression to the intestinal flora can affect its balance and allow harmful bacteria to grow: stress, overuse of medication, unhealthy diet and/or low in fiber, infections, diseases, or
taking antibiotics.

The enteric nervous system

Studies conducted by Michael D. Gershon, a researcher at Columbia University, US, have shown that the enteric nervous system (intestinal), called also the second brains contains over 100 million neurons and secretes at least 20 neurotransmitters identical to those found in the brain. It participates in the management of our emotions and it is involved in pain control and regulation of thermoregulation, food, and sexual behavior, sleep-wake cycle, pain and anxiety.
In summary, our intestine is a key element for our health and mood. It is, therefore, important to maintain a rich and balanced intestinal flora.

Choose high-quality Probiotics and Prebiotics for a natural, fast and gentle action:

Four Probiotics to restore and balance the intestinal flora

Lactobacillus Rhamnosus
This bacterium has been the subject of considerable research. It is often used in dairy products in Finland and the US, where its virtues to enhance immunity are sought[2]:
– Lactobacillus rhamnosus protects against acute diarrhea[3] caused by viral gastroenteritis.
– Associated to Bifidobacterium longum, it proves a great efficiency to prevent turista – shown by numerous clinical[4] trials

– Associated with Bifidobacterium longum, it acts on the eradication of infections by the helical pylori – this latter being the cause of many gastritis and most peptic ulcers. In 2009, two meta-analyses have proven the effectiveness of probiotics to help cure this infection and mitigate its adverse effects[5,6].
– It improves the condition of people suffering from irritable bowel syndrome by alleviating pain, flatulence, bloating and regulating intestinal[7] transit.
– Lactobacillus rhamnosus reduces the protective layer in the intestines, especially in cases of alcohol[8] problems.
– It avoids complications due to taking an antibiotic[9] treatment.
– It has a powerful action on the vaginal infections, by intervening in the vaginal flora balance[10].
– Lactobacillus rhamnosus has significant impacts on anxiety and obesity by slowing the release of corticotropin-releasing hormones (CRH) that control the activity of the hypothalamic-pituitary-adrena axis[11].

Bifidobacterium Longum
Among the 400 species of bacteria of the intestinal flora, Bifidobacterium longum is one of the most common and most studied. It would constitute more than 95% of the intestinal flora of breastfed[12] infants, which would explain their greater resistance to infection.

Among its actions, it has been verified that:
– Associated with Lactobacillus rhamnosus, she proved great effectiveness to prevent the “turista” (see previous paragraph).
– Associated with Lactobacillus rhamnosus, it acts on the eradication of infections by the helico pylori (see previous paragraph).
– Bifidobacterium longum improves the condition of people suffering from irritable bowel syndrome[13].
– It relieves the symptoms of lactose intolerance[14].
– It calms the inflammation associated with Crohn’s disease or colitis.
– It prevents relapses of ulcerative colitis by extending remissions[15].
– Lactic acid produced by Bifidobacterium longum has anti-carcinogenic and anti-mutagenic properties. Studies have proven its effects on tumor[16].

Lactobacillus Acidophilus
This bacterium was isolated, in 1900, in the faeces of infants and named Bacillus acidophilus because of its remarkable tolerance to acidity.

It has many properties:
– A proven effectiveness in preventing diarrhea caused by antibiotics, in combination with Bifidobacterium longum.
– Lactobacillus acidiphilus specifically attenuates intestinal problems caused by anxiety[17].
– It has been proven it has an antagonistic activity against pathogens of food products such as Staphylococcus aureus, Salmonella typhimurium, Escherichia coli and Clostridium perfringens[18].
– It is known to have the ability to metabolize lactose in the small intestine and thus facilitate its digestion[19].
– It is anti-carcinogenic. An experiment conducted in rats shows a lower incidence of colon cancer after a period of 20 weeks, with the administration of the bacteria[20].
– It easily adheres to the wall of the intestine, which facilitates its implantation in a cure of probiotics[21].
– Finally, Bacillus acidophilus can treat or prevent vaginal infections. In 2009, researchers have compared the effectiveness of various treatments against bacterial vaginosis, one of the most common causes of vaginitis[22]. They concluded that the local use of lactobacilli is more effective than antibiotics prescribed orally (clindamycin, metronidazole).

Bifidobacterium Infantis
This strain of bacteria is acquired naturally during childbirth and then with breastfeeding[23], which would explain the greater resistance to infections in breastfed infants[24].
Irritable bowel syndrome is accompanied by a significant reduction in the amount of intraluminal bifidobacteria, with consequences such as colic gas production and impaired motility of the intestinal tract.
Ingesting a probiotic complement of the Bifidobacterium Infantis strain allows to re-seed good bacteria and to act effectively and without side effects for:
– Reduce pain due to irritable bowel syndrome. Indeed, it has been demonstrated, for example, that a complex of Bifidobacterium Infantis and Longum is associated with better control of intestinal pain and improves quality of life compared to placebo in children with SCI[25]
– Decrease “bloating” which is particularly difficult to treat and often categorized as the most intrusive symptom by those affected by SCI[26],
– Normalize intestinal transit and cause overall relief in patients with SCI,
– Act on the psychological factors of the SCI: Bifidobacterium Infantis is considered as a “psychobiotic”, with anti-inflammatory actions and a real ability to reduce the activity of the hypothalamic-pituitary-adrenal axis which maintains the capacity of the organism to respond to acute and prolonged stressors. Results of large-scale placebo-controlled studies are expected[27]

Two Prebiotics to reinforce the action of the Probiotics

Lactobacillus Acidophilus
This bacterium was isolated, in 1900, in the faeces of infants and named Bacillus acidophilus because of its remarkable tolerance to acidity.

It has many properties:
– A proven effectiveness in preventing diarrhea caused by antibiotics, in combination with Bifidobacterium longum.
– Lactobacillus acidiphilus specifically attenuates intestinal problems caused by anxiety[17].
– It has been proven it has an antagonistic activity against pathogens of food products such as Staphylococcus aureus, Salmonella typhimurium, Escherichia coli and Clostridium perfringens[18].
– It is known to have the ability to metabolize lactose in the small intestine and thus facilitate its digestion[19].
– It is anti-carcinogenic. An experiment conducted in rats shows a lower incidence of colon cancer after a period of 20 weeks, with the administration of the bacteria[20].
– It easily adheres to the wall of the intestine, which facilitates its implantation in a cure of probiotics[21].
– Finally, Bacillus acidophilus can treat or prevent vaginal infections. In 2009, researchers have compared the effectiveness of various treatments against bacterial vaginosis, one of the most common causes of vaginitis[22]. They concluded that the local use of lactobacilli is more effective than antibiotics prescribed orally (clindamycin, metronidazole).

Ribose
Ribose is a sugar useful to all living organisms. It plays three major roles:
– It is a component of adenosine triphosphate (ATP), the fuel of cell that meets the body’s energy needs.
– It has an action on the UTP (Uridine triphosphate): a compound that provides energy, helps the muscle recovery and promotes the synthesis of glycogen.
– It enables the production of ribonucleic acid (RNA) for the transcription of the genetic[33] code.

Ribose is therefore particularly important to stimulate all the body and reinforce the bacteria in the intestinal flora.
– It is composed of a studied mixture of three different Probiotics for further action and a full and rapid colonization of the intestine,
– To these Probiotics are associated two Prebiotics to reinforce their action, this complex contains strains recognized for their effectiveness and their complementary action,
– It reinforces the immune system,
– It improves the transit
– It restores the intestinal flora,
– It reduces the recurrence of vaginal mycoses,
– It helps to prevent the “turista” 15 days to 1 month before the trip,
– It avoids the undesirable effects of a long antibiotic therapy,
– The excellent tolerance achieved through the synergy of these components allows being used in the long term without side effects,
– It works by “Sustained release” to pass the gastric barrier,
– It is made from 100% natural active, with a “smart” formulation for a synergistic and effective action of the components,
– It is completely bioavailable,
Biocompatible, it respects the body and acts in depth on our vitality.

Sources:

[1] Haddad PS, Azar GA, et al. Natural health products, modulation of immune function and prevention of chronic diseases. Evid Based Complement Alternat Med. 2005 Dec;2(4):513-20. Full text: http://ecam.oxfordjournals.org
[2]  Doctissimo.fr website accessed September 11, 2014 « Il y a probiotiques et probiotiques »
[3] Szajewska H, Mrukowicz JZ. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr. 2001 Oct;33 Suppl 2:S17-25.
[4] McFarland LV. Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Med Infect Dis. 2007 Mar;5(2):97-105. Epub 2005 Dec 5.
[5] Sachdeva A, Nagpal J. Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials. Eur J Gastroenterol Hepatol. 2009 Jan;21(1):45-53.
[6] Zou J, Dong J, Yu X. Meta-analysis: Lactobacillus containing quadruple t! herapy versus standard triple first-line therapy for Helicobacter pylori eradication. Helicobacter. 2009 Oct;14(5):97-107.
[7] Nikfar S, Rahimi R, et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Dis Colon Rectum. 2008 Dec;51(12):1775-80. Epub 2008 May 9.
[8] Wang, Y.; Liu, Y.; Sidhu, A.; Ma, Z.; McClain, C.; Feng, W. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury. Am J Physiol Gastrointest Liver Physiol 303 (1): G32–41. doi:10.1152/ajpgi.00024.2012. PMID 22538402. Forsyth, CB.; Farhadi, A.; Jakate, SM.; Tang, Y.; Shaikh, M.; Keshavarzian, A. (Mar 2009). Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 43 (2): 163–72. doi:10.1016/j.alcohol.2008.12.009. PMID 19251117.
[9] McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006 Apr;101(4):812-22. http://www.ncbi.nlm.nih.gov/pubmed/16635227
[10] Oduyebo OO, Anorlu RI, Ogunsola FT. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD006055. Revi! ew. http://www.ncbi.nlm.nih.gov/pubmed/19588379
[11] Alison C Bested, Alan C Logan, Eva M Selhub. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials. Gut Pathog. 2013; 5: 4. Published online 2013 March 16. doi: 10.1186/1757-4749-5-4 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605358/
[12] Yoshioka H. et al., Development of the normal intestinal flora and its clinical significance in infants and children, Bifidobacteria and Microflora, 1991, 10(1): 11-17.
[13] Nikfar S, Rahimi R, et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Dis Colon Rectum. 2008 Dec;51(12):1775-80. Epub 2008 May 9.
[14] He T1, Priebe MG, Zhong Y, Huang C, Harmsen HJ, Raangs GC, Antoine JM, Welling GW, Vonk RJ. Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. J Appl Microbiol. 2008 Feb;104(2):595-604. Epub 2007 Oct 9. http://www.ncbi.nlm.nih.gov/pubmed/17927751.
[15] Sang LX, Chang B, et al. Remission induction and maintenance effect of probiotics on ulcerative colitis: a meta-analysis. World JGastroenterol. 2010 Apr 21;16(15):1908-15. http://www.ncbi.nlm.nih.gov/pubmed/20397271
[16] Benno, Y.; Mitsuoka, T. (1992). Impact of Bifidobacterium longum on human fecal microflora. Microbiology and immunology 36 (7): 683–694
[17] Diop L, Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial, Nutr Res. 2008 Jan;28(1):1-5. doi: 10.1016/j.nutres.2007.10.001
[18] M.E. Sanders, Invited Review: The Scientific Basis of Lactobacillus acidophilus NCFM Functionality as a Probiotic, Journal of Dairy Science, vol. 84, no 2,‎ 2001-02, p. 319-331 ISSN 0022-0302, DOI 10.3168/jds.S0022-0302(01)74481-5
[19] R G Montes, Effect of milks inoculated with Lactobacillus acidophilus or a yogurt starter culture in lactose-maldigesting children, Journal of dairy science, vol. 78, no 8,‎ 1995-08, p. 1657-1664 (ISSN 0022-0302, DOI 10.3168/jds.S0022-0302(95)76790-X)
[20] B R Goldin, Alt! erations of the intestinal microflora by diet, oral antibiotics, and Lactobacillus: decreased production of free amines from aromatic nitro compounds, azo dyes, and glucuronides, Journal of the National Cancer Institute, vol. 73, no 3,‎ 1984-09, p. 689-695 (ISSN 0027-8874)
[21] Site de Opticbac Probiotics, What is acidophilus
[22] Oduyebo OO, Anorlu RI, Ogunsola FT. Cochrane Database Syst Rev. 2009 Jul. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. 8;(3):CD006055. Review.
[23] Mark A. Underwood, J. Bruce German, Carlito B. Lebrilla, David A. Mills. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatr Res. Author manuscript; available in PMC 2015 March 5. Étude ici
[24] Yoshioka H. et al., Development of the normal intestinal flora and its clinical significance in infants and children, Bifidobacteria and Microflora, 1991, 10(1): 11-17.

[25] https://www.ncbi.nlm.nih.gov/pubmed/27306945
[26] Nikfar 171

[27] https://www.ncbi.nlm.nih.gov/pubmed/23759244
[28] Mao B, D Li, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W. Métagénomique Regards sur les Effets des fructo-oligosaccharides (FOS) sur la composition du microbiote fécal chez la souris. J Agric Food Chem . 28 janvier 2015; 63 (3): 856-63. doi: 10.1021 / jf505156h. Epub 2015 le 17 janvier. http://www.ncbi.nlm.nih.gov/pubmed/25598242
[29] Moro G, Minoli I, Mosca M et al. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants JPGN 2002; 34: 291–295
[30] Miller TL, Wolin MJ. Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora. Appl Environ Microbiol 1996; 62: 1589–92!
[31]1Bruno-Barcena JM, Azcarate-Peril MA. Galacto-oligosaccharides and Colorectal Cancer: Feeding our Intestinal Probiome. J Funct Foods. 2015 Jan;12:92-108. PMID: 25584074 [PubMed] http://www.ncbi.nlm.nih.gov/pubmed/25584074
[32] Steer TE1, Johnson IT, Gee JM, Gibson GR. Metabolism of the soybean isoflavone glycoside genistin in vitro by human gut bacteria and the effect of prebiotics. http://www.ncbi.nlm.nih.gov/pubmed/13129470
[33] Masantenaturelle.com website accessed September 11, 2014, une seconde vie grâce au Ribose

Image Sources: Canva, Enteric Nervous System by VectorMine from Depositphotos
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Hypertension : The Natural Solution

Hypertension : The Natural Solution

Arterial hypertension (or high blood pressure) affects around 20% of the French adult population, and it is also the most frequent cause of cardiovascular problems. The risk of suffering from it increases with age. A person is considered to have high blood pressure when diastolic pressure is over nine and systolic pressure is over 14 – being respectively the lower and upper numbers recorded when measuring blood pressure.

High blood pressure is considered as a “silent” or “insidious” disease, as many people do not realize that they have it until symptoms arise. Besides, very few people regularly get their blood pressure checked. Yet, that illness causes major cardiovascular complications and leads to 62% of strokes as per the WHO. The excessive mechanical pressure upon the arteries causes anomalies and fosters rigid artery walls. It therefore increases the risk of atheroma appearing or worsening.

The most frequently affected arteries are the carotid (brain), coronary (heart), kidneys and lower limbs. Thus, some risks are heightened, such as the following consequences: strokes, ischemic heart disease (angina and heart attacks), peripheral arterial disease (narrowing of the arteries supplying blood to the legs) and chronic kidney failure. The fragilized arteries may also require dialysis in the long term. Moreover, the high blood pressure indirectly increases the heart’s activity – because it maintains a constant blood flow – and then leads to left ventricular hypertrophy and gradual loss of its contractile activity (possible outcome is heart failure). In that respect, high blood pressure is mainly critical because of its long-term consequences on various organs. Conventional medicine offers a range of “solutions”: diuretics, beta-blockers (to reduce the heart beat) and calcium channel blockers (to diminish vascular resistance) etc. However, these treatments are symptomatic and go along with side effects.

Naturally regulating blood flow and blood pressure helps limiting the risks of heart diseases, while effectively protecting the body.

Which plants are most effective?

Red vine: blood flow regulation

The EMA (European Medicines Agency) has acknowledged red vine’s effectiveness in treating circulation problems (venous insufficiency and varicose veins), capillary fragility  (small blood vessels that form under the skin), burns and irritations caused by haemorrhoids. The Agency also states that red vine holds some antioxidant, anti-inflammatory and anti-oedema virtues; it protects the liver as well, and procures antimicrobial and diuretic actions. These properties have been tested by scientific researches on grape polyphenols, including resveratrol and oligomeric proanthocyanidin complexes (OPC).

Resveratrol (grape skins) is a powerful antioxidant which has shown promising anti-ageing effects on some primitive animal species. Overall, it protects and s timulates the circulatory system.

Anthocyanins (red vine leaves) reduce capillary permeability and increase their resistance, thus preventing the venous circulation to stagnate. In grapes, this action is potentialized by the presence of tannins, astringents and vasoconstrictors (the OPC): they facilitate venous return. Refer to the properties of grape seeds for further information.

Therefore, consuming red vine extracts helps protecting the venous system by maintaining the elastic fibers, re-establishes circulation, prevents and reabsorbs oedema.

Grape seeds : better circulation

Grape seeds are particularly rich in OPC antioxidant, which are 20 times as efficient as Vitamin C and 50 times as efficient as Vitamin E. OPC have a perennial impact on free radicals, the latter being responsible for various disorders within the circulatory system. Indeed, free radicals destroy cellular membrane, damage collagen and lead to the hardening of arteries (increased risk of high blood pressure). As opposed to those disorders, OPC improve blood vessel elasticity, prevent blood platelets from sticking together, hence reducing the risk of blood clots and aphasia. Moreover, those complexes also help diminishing the amount of cholesterol deposed on blood vessel walls. Grape seeds finally boost exceptional anti-inflammatory and anti-oedema properties.

Numerous clinical studies have been conducted in France to demonstrate how grape seeds can be used to treat capillary fragility and varicose veins. In a double-blind study, 71 patients with venous insufficiency were divided in two groups. Each group was given a daily dose of 300mg of either grape seed anthocyanidins or a placebo. 75% of the former showed significant reduction in functional symptoms, compared to 41% of the latter. Tests show that administering anthocyanidins enhances venous tone in patients with extensive varicose veins. Another clinical trial featured two groups of geriatric patients suffering from low capillary resistance. Each group was treated with 100-150mg of either anthocyanidins or placebo. 50% of the former showed improved capillary resistance after two weeks.

Blueberry to strengthen the capillaries

Blueberries are rich in Vitamin C and contain iron, magnesium, potassium and phosphorous. They are also composed of a record-breaking quantity of flavonoids with anti-cancerous, antioxidant and fluidizing properties. Apart from other phenolic components, blueberries contain a high concentration of anthocyanins, which positive effects have been described above.

Numerous clinical and epidemiological studies have sorted out the causality that exists in the relationship between the consumption of blueberries (flavonoids) and the reduction of cardiovascular and degenerative diseases.

The phenolic compounds contained in blueberries should also reduce blood lipid oxidation, consequence of oxidative stress and inflammation of the vascular system. As a matter of fact, a placebo-controlled and double-blind study of 60 patients with chronic venous insufficiency showed a substantially improved condition after 30 days of treatment with blueberry extracts.

To conclude, we have seen that blueberries strengthen the capillaries by protecting them from oxidation, improve the contractile function of blood vessels and stimulate the regeneration of the rods in the retina. For the record, RAF pilots used to eat large quantities of blueberries before nocturnal flights during WW2 to improve their eyesight.

Meadowsweet to improve blood flow

Meadowsweet has been known for centuries and among other components contains salicylic derivatives (including salicyl aldehyde, methyl salicylate etc), which are forerunners of acetylsalicylic acid, universally known as aspirin. Just like aspirin, meadowsweet has 
anti-inflammatory and analgesic properties, yet it also has a major advantage over aspirin, as it is extremely safe. Unlike aspirin (synthetic), which causes ulcers and bleeding in the stomach when used for extended periods of time, meadowsweet combats gastric acid. It also contains flavonoids, tannins and a number of trace elements, such as iron, sulphur and calcium.

Meadowsweet has the following recognized properties:

Anti-inflammatory and anti-rheumatic and is recommended for chronic pain, migraines, throat infections, laryngitis etc.
– Thins the blood (Vitamin K).
– Fever reduction (salicylic derivatives).
– Gastroesophageal anti-acidic properties.
– Diuretic and astringent (flavonoids and mineral salts): it powerfully clears uric acid from the body.
Intestinal antispasmodic and urinary pain sedative.
– Diarrhoea prevention.

It is also recommended to treat cellulite, arteriosclerosis and all diseases related to the body being overloaded with waste.

Olive leaves to naturally lower blood pressure

The ‘fashion’ for a Mediterranean diet is the result of a significant body of research which has demonstrated that the death rate from heart disease is lower in olive oil-consuming countries.

Moreover, olive leaf extract is proven to be effective, making it a safe preventive and therapeutic treatment for high blood pressure. It improves circulation by relaxing and dilating the arteries and also aids diuresis, reduces oedema (fluid retention) and blood urea nitrogen levels.

Why? Because it contains components such as :

Oleuropein, a significant oxidation inhibitor.
Oleuropeoside lowers blood pressure and is effective against the effects of high blood pressure, such as headaches, dizziness and buzzing in the ears. It also has diuretic, hypoglycaemic and anti-spasmodic properties and vasodilatory and anti-arrhythmic action.,
Flavonoids – these are antioxidants which help to neutralise free radicals and play an important part in protecting artery walls.

According to a University of Milan study, olive leaves help prevent arteriosclerosis and coronary diseases. The properties of olive leaves enable them to reduce ‘bad’ cholesterol (LDL) and increase ‘good’ cholesterol (HDL), which in particular makes them an invaluable complement when treating non-insulin dependent diabetes.

Blackcurrant – anti-oxidant and purifying properties

Blackcurrant berries (just like black grapes) owe their intense colour to complex molecules, anthocyanins, which have properties similar to those of Vitamin P, and trap free radicals. They also contain three times more Vitamin C than oranges and are rich in Pro-Vitamin A and Vitamin E. Recent research has found that blackcurrant’s anti-oxidant power comes from a synergy of its various components (anthocyanins, quercetin, and Vitamins A, C and E).

Blackcurrants are also vasoprotective and venotonic. They boost capillary resistance and 
permeability, thus improving microcirculation. In this respect, they can be used to prevent and treat symptoms of capillary fragility (rosacea and broken blood vessels on the legs). Blackcurrant in particular counters blood vessel wall aging.

We also know that blackcurrant seeds are rich in essential fatty acids from the Omega 3 family (such as alpha-linoleic acid and stearidonic acid) and the Omega 6 family (gamma-linolenic acid, for example). These fatty acids are thought to have blood pressure lowering and 
anti-inflammatory properties.

They are also unique because the body is able to effectively assimilate the elements contained in the seeds. They are circulated in the blood and then excreted in urine and are effective along the length of the tract.

A blend of six plants acts effectively and comprehensively

Each of the aforementioned plants contains components with their own unique properties and which seem similar. However, it is important to stress that these plants need to be “combined” to achieve a targeted and comprehensive effect.

Only a complex of active ingredients enables the body to effectively regulate blood flow and blood pressure by acting on several “fronts”. Please be aware: consuming complexes of plant extracts can be dangerous and in light of the differing compositions of natural products on the market, it is vital to check the origin, dosage and concentration of the main active ingredients inproducts. Moreover, while many products are available containing dry extracts taken from one or all six of the plants I have mentioned, few offer carefully-developed blends to ensure maximum effectiveness in order to have a comprehensive and synergetic impact. Indeed, active ingredient synergy is an additional piece of information for the body, telling it where and when the active ingredients will act, without ever interacting!

– It contains a carefully-developed blend of dry extracts of red vine leaf, grape seed, blueberry, meadowsweet, olive leaf and blackcurrant, known to reduce high blood pressure and aid blood flow

– The complex also contains bearberry, galega and grapefruit, known for their hypoglycaemic properties
– The complex contains 100% natural active ingredients, with a “smart” and sequential formula designed to ensure that the ingredients act effectively and in synergy
– It is fully bio-available and bio-compatible
– It acts on the circulatory system as a whole and effectively regulates blood pressure
– The complex contains 100% natural active ingredients, with a “smart” and sequential formula designed to ensure that the ingredients act effectively and in synergy
– It is fully bio-available and bio-compatible
– It acts on the circulatory system as a whole and effectively regulates blood pressure
– The complex aids microcirculation thus acting on the whole vein system
– The complex ensures a healthy blood balance by acting on sugars and cholesterol
– It is compatible with medical high blood pressure treatments

As the result of the latest drug innovations, it comes in the form of “controlled-release” micro-granules in order to ensure that the active ingredients are released in the body in an extended and targeted fashion so that optimum results are achieved.

The result of the latest pharmaceutical innovations, it is presented in a special microgranular form.

The microgranules have a biocompatible neutral core (patented), and a semi-permeable membrane that protects and releases 96% of the active ingredients (no contamination by dust and moisture, no risk of sticky clumping in a wet environment).

The microgranules also provide greater protection in the stomach, thus eliminating any side effects

They ensure improved compliance due to the reduced dosage, and greater comfort due to masking the taste and odour of plant extracts.

Sources:
[1] Source INSERM – www.inserm.fr/thematiques/circulation-metabolisme-nutrition/dossiers-d-information/hypertension-arterielle
[2] EMA study:
[3] Henriet JP. Exemplary study for a phlebotropic substance, the EIVE Study [translated from French]. Fairfield, Conn: Primary Source; not dated. Study mentioned and summarised in: Natural Standard (Ed). Herbs & Supplements – Grape seed (Vitis vinifera, Vitis coignetiae), Nature Medicine Quality Standard. http://www.naturalstandard.com/
[4] Delacroix P. Double-blind study of Endotelon W in chronic venous insufficiency [translated from French]. La Revue de Médecine. Aug/Sept.1981;no.27-28:1793- 1802. Study mentioned and summarised in: Natural Standard (Ed). Foods, Herbs & Supplements – Grape seed (Vitis vinifera, Vitis coignetiae), Nature Medicine Quality Standard. www.naturalstandard.com
[5] Pizzorno JE Jr, Murray Michael T (Ed). Textbook of Natural Medicine, Churchill Livingstone, US, 1999. p. 994.
[6] Royer R.J., Schmidt C.L., “Evaluation of venotropic drugs by venous gap plethysmography. A study of procyanidolic oligomers “, Sem. Hop., 1981, 57:2009-2013.
[7] Dartenuc J.Y., Marache P., Choussat H., “Capillary resistance in geriatry. A study of a microangioprotector Endotelon”, Bor. Med., 1980, 13:903-907.
[8] Neto CC. Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res. 2007 Jun; 51(6):652-64.
[9] Gatta L., “Experimental single-blind study: 60 pts with venous insufficiency received bilberry extract equivalent to 173 mg anthocyanins daily of placebo for 30 days”, Fitoterapia, 1988, 115:109-116.
[10] Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects.
[11]Pizzorno JE Jr, Murray Michael T (Ed). Textbook of Natural Medicine, Churchill Livingstone, US, 1999. p. 994.
[12] Susalit E, Agus, N Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Comparison with Captopril., Effendi I et al. Phytomedicine. 2010 Oct 29.
[13] Syed Haris Omar, Oleuropein in Olive and its Pharmacological Effects.
[14] Research on blackcurrants: “Antioxidant Activity of Black Currant Anthocyanin Aglycons and Their Glycosides Measured by Chemiluminescence in a Neutral pH Region and in Human Plasma”. Matsumoto, H., Y. Nakamura, et al. (2002). J. Agric. Food Chem. 50(18): 5034-5037
[15] Thesis on “Le Cassis (ribes nigrum L.) : études botanique, chimique et effets thérapeutiques”, Stéphanie GERBAKA, Grenoble 2013

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