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The natural active ingredients for beauty by Activa

The natural active ingredients
for beauty by Activa

Skin & Wrinkles

The different layers of the skin and their components are affected by endogenous and environmental factors such as ageing, sunlight exposure, chemicals and mechanical damage.
To maintain and improve the condition of the skin, a variety of skincare products are widely available, but they do not act in depth. Nutrition is known to influence the condition of the skin. Most of what we know of the relationship between nutrients and the dermis comes from the incidence of skin problems due to nutritional deficiencies.  It has been shown that improving the diet improves the condition of the skin[1,2,3]. In particular, one study showed that the wrinkles of elderly people of various ethnic origins living in a sun-exposed area were influenced by the types of food they consumed: 32% of skin variation was predicted by dietary intake.

Research on skin ageing is now focused on cosmetic nutrients, for skin in-depth maintenance and improvement.
As the most abundant protein in the human body, collagen peptide supplementation has been the subject of much research. The effects of a collagen hydrolysate mixture daily intake (including 5 g of type I collagen hydrolysate) on the skin of 25 women with dry, rough skin were studied[4].

After, six weeks of intake, they observed:

  • an increase in the moisture of the cheeks, face, forearms and back of the neck
  • an improvement of viscoelastic properties (elasticity)
  • an improvement of skin smoothness, with less wrinkles and roughness

How to keep your skin looking young?

1 to 2 caps of SkinGlow a day

Hair & Nails

The growth and vitality of the hair depend on the nutrients and hormones the blood carries to its root: the only effective way to deeply and durably act on its health or to “heal” it is therefore to nourish it from within.

Here are 3 of the main factors of hair loss

  • Hormonal imbalance: androgenetic alopecia
    A very common condition that affects about 50% of men. It also affects about 15% of women aged 40 and 75% of women over 65. The cause of this abnormal hair loss is linked to the hyperactivity of an enzyme, 5 alpha-reductase, involved in the transformation of testosterone into Di Hydro Testosterone (DHT).
    An excessively high level of 5 alpha-reductase will result in the modification of the duration of the hair cycles (shortened growth phase), causing first a thinning of the hair, then a progressive and finally e  total disappearance on large areas of the scalp.
  • Oxidation: diffuse alopecia
    Characterised by fine and thinning hair on the entire scalp, it affects mainly women.
    It is most often due to damage caused by free radicals generated by external factors such as pollution, stress, quality of life… Free radicals maintain the inflammation of tissues, promoting the ageing of hair follicle cells (root) and shortening the life cycle of hair.
  • Microcirculation: Deficiency loss
    It is scientifically recognised that a blood nutrient deficiency, can cause abnormal hair loss, called deficiency loss. The blood supply is anaemic, resulting in shorter hair cycles.

Nails are also sensitive to good nutrition, pollution and harsh treatments. Keratin, make up the cell tissues in nails. Stimulating the production of keratin in our body will support healthy growth and strengthen them.

Activa Well Being Hair contains a blend of powerful active ingredients from plants known to fight hair loss, stimulate growth and strengthen nails.

  • Saw Palmetto acts on hair growth
  • Nettle remineralizes and provides essential vitamins
  • Blueberries stimulate and stop oxidation to promote regrowth and growth
  • Watercress and Marigold extracts fight against free radicals and reinforce the quality and vitality of hair and nail by stimulating keratin production.

Manufactured in France using the technology of microgranules, Activa products offer gastroprotection, controlled release, biocompatibility and close to 100% bioavailability.

For optimal beauty results combining Activa SkinGlow with Activa Hair will help repair damaged and tired hair, promote nail strength and act on wrinkles and fine lines from within.

1 to 2 caps of Hair a day

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[1] Boelsma E, Hendriks HFJ, Roza L. Nutritional skin care: health effects of micronutrients and fatty acids. Am J Clin Nutr 2001;73:853–64.
[2] Purba M, Kouris-Blazos A,Wattanapenpaiboon N, et al. Skin wrinkling: can food make a difference? J Am Coll Nutr 2001;20:71–80.

[3] Boelsma E et al, 2003. Human skin condition and its associations with nutrient concentrations in serum and diet. Am J Clin Nutr, Vol. 77, No. 2, 348-355.
[4] Matsumoto H, Ohara H, Ito K, Nakamura Y, Takahashi S. Clinical effect of fish type I collagen hydrolysate on skin properties. ITE Lett Batteries New Technol Med 2006;7:386-390.
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Melatonin to reduce stress and anxiety

Melatonin to reduce stress and anxiety

Stress is natural. It is the organism’s innate physiological response to an unexpected event perceived as life threatening. It enables the body to quickly slow down “non-vital” functions and focus all possible energy and resources to fight or escape from this danger; this is commonly called the “flight or fight” response.

Adrenaline and cortisol: 2 hormones involved in stress

Adrenaline is a “warrior hormone” that mobilises all available energy to give the muscular strength to react.
Cortisol transforms fat into sugar and mobilises sugar energy to a specific location in the body. Some organs and functions then become secondary or “on hold”. When its level  returns to normal it will send a hunger response to the brain to replenish its reserves. In a regular situation, the cortisol maintains the energy balance of the body.

In a situation of recurrent stress, cortisol, and adrenaline are constantly secreted, which leads to a high heart rate, high blood pressure, and high blood sugar. The body constantly renews its reserves and stores them as fat. This continuous secretion can have a lot of negative consequences on health, such as diabetes and obesity, cardiovascular problems, memory disorders, learning difficulties, depression, and in case of cortisol depletion (adrenal fatigue) anxiety and exhaustion.

Melatonin: more than just a sleep hormone:

Melatonin is a hormone produced by the epiphysis gland, it is also called the sleep hormone. Its production is the antagonist to that of cortisol. It is secreted when the daylight reduces, inducing relaxation and preparing the body to sleep. Its peak secretion is around 3 am, but exposure to light affects its secretion and is one of the reasons people experience sleep difficulties when they travel as the exposure to light is changed and it affects natural melatonin secretion. For this reason, melatonin intake has been found to be very efficient in helping regulate the “sleep-wake” cycle. Moreover, with excessive exposure to non-natural light, the melatonin secretion of many individuals is disrupted, resulting in difficulties in falling asleep.

At night melatonin is released

Like a dance, cortisol, and melatonin follow a circadian rhythm and are therefore essential in the sleep and wake cycles. Cortisol induces activity in the body, it’s peak secretion is between 6 and 8 in the morning, just before waking up, whereas melatonin induces calm, secreted when night falls, with a peak secretion around 3 am. It has a strong action on anxiety and some studies have shown that when associated with light it decreases aggressive behavior. Getting ample natural sunlight is crucial as it directly affects the circadian rhythm, which, in turn, has a significant impact on our mood.

Studies have shown that melatonin plays a role in reducing stress-related psychological disturbances, anxiety, and agitation by bringing the circadian rhythm back in sync. This study has demonstrated the antidepressant potential of melatonin (1,2)

Melatonin goes beyond enhancing sleep quality; it can also alleviate stress, anxiety, and aggression, foster tranquility, and restore a sense of serenity.

The natural solution

Notes:

[1] 42. Jansen S, Forbes D, Duncan V, Morgan D, Malouf R. Melatonin for the treatment of dementia.Cochrane Database Syst Rev. 2011;(1):CD003802. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003802.pub3/abstract

[2] Detanico BC 1 , Piato AL , Freitas JJ , Lhullier FL , Hidalgo MP , Caumo W , ElisabetskyE .Antidepressant-like effects of melatonin in the mouse chronic mild stress model. EurJ Pharmacol 2009 1 avril; 607 (1-3): 121-5. doi: 10.1016 / j.ejphar.2009.02.037. Epub2009 le 26 février. https://pubmed.ncbi.nlm.nih.gov/19249298/

Image Source: Depositphotos

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Relief and Prevention of Gastritis

Relief and Prevention of Gastritis

Who has never suffered from gastritis? In France, gastritis affects 30% of French adults and 50% of French people over 50! The individuals affected use standard remedies, hence subjected to many relapses.

Gastritis is a chronic inflammation of the gastric mucosa – the membrane lining the stomach. It might be an isolated incident – caused by a bacterium or a virus – but it is mostly chronicle. It creates intense heartburn and digestive disorders.

Gastritis may result either from a frequent autoimmune reaction – induced by Helicobacter pylori (observed in 80% of cases) or from external and chemical aggressions (e.g. consumption of alcohol, tobacco or some medicines). The trigger is not so easily identified, though it appears that stress might often be involved – especially chronic, as a direct or indirect cause.

Cures exist either to help reducing or neutralizing the heartburn, or to support the healing of ulcers. Indeed, antibiotics are commonly used when a Helicobacter pylori infection is diagnosed. Overall, it is recommended to refrain from smoking, drinking alcohol or taking medications which are likely to cause heartburn (as a side effect). Warnings are also valid regarding strict diets.

Alternatives exist for the natural and permanent relief and prevention of gastritis, namely …

Fenugreek : a potent anti-ulcer agent

Fenugreek, (Trigonella foenum graecum) is one of the oldest medicinal plants on Earth. This Mediterranean leguminous plant is highly rich in oligo elements and amino acids. Indeed, it contains phosphorus, iron, Sulphur, nicotinic acid, alkaloids, flavonoids, carbohydrates, vitamins A, B1, and C, magnesium, calcium, lecithin, proteins (30%) and steroidal saponins. Overall, those elements contribute to the synthesis of cholesterol and fibers.

Fenugreek stimulates the appetite and is known for its anti-ulcer properties. Several studies have been conducted to investigate its impact on gastric ulcers (1,2) by comparison with other drugs – such as omeprazole. They showed that Fenugreek seeds exert a potent cryoprotective impact thanks to:

– Its mucilage and galactomannans, which protect the gastric mucosa and functions, and both the small intestine and colon. Indeed, they help soothing gastrointestinal inflammation by forming an efficient protection of the intestinal environment,
– Its quick and powerful inhibitory action upon the secretion of hydrochloric acid (by parietal cells of the stomach),
– Its significant role in the reduction in lipid peroxidation – caused by ethanol – and red cell deterioration by sustaining the activity of antioxidant enzymes (catalase and SOD). Lipid peroxidation plays a major role in the inflammation of the gastric mucosa and the formation of lesions. The mentioned study also highlighted that Fenugreek seeds are more effective than omeprazole as a preventive treatment.

The above elements lead to the conclusion that Fenugreek holds a real anti-ulcer potential.

Besides, Fenugreek acts as a tonic when fatigue kicks in, as a pancreatic stimulant and as an anti-inflammatory. Fenugreek leaves are bitter, hence fortifying the liver and stimulating the production of bile. The latter is more easily expulsed from the gallbladder, thus stimulating the biliary excretion of cholesterol while simultaneously reducing both levels of triglycerides and LDL cholesterol in the blood. Finally, further studies have found out that Fenugreek could also have a preventive effect on the onset of colon, breast and gallbladder cancers.

Fenugreek Hydroxy Isoleucine

Researchers discovered that Fenugreek seeds also contain an unconventional amino acid with highly interesting insulin-stimulant properties (3) – the 4-hydroxyisoleucine. This molecule does not exist either in human or animal cells, and stimulates the secretion of insulin by targeting pancreatic cells. The main interest of hydroxy isoleucine is that it truly differs from sulfonylureas, which are currently used in the treatment of diabetes: indeed, the latter causes hypoglycemic side effects(4), as opposed to 4-hydroxyisoleucine. Nonetheless, it is necessary to specify that only 100% natural Fenugreek extracts provide the efficient quantity of 20% hydroxyisoleucine.

Melissa : Antispasmodic and Choleretic

Melissa (lemon balm) has been famous since the time of ancient Greece for its soothing and digestive properties. It especially helps regulating nerve impulses, hence reducing stomach and colon spasms.
 

Different studies (5,6) have drawn attention on the active substances of lemon balm, such as:
– terpene aldehydes, which have antiviral, calming and sedative properties. They have also antihypertensive, stomachic, antibacterial and anti-inflammatory qualities,

– terpene alcohols, which exert a neurotonic, liver stimulating and immunomodulating effects. They influence emotional and mental states,
– carophyllene contained in sesquiterpenes, which hold has anti-inflammatory, anti-colic and antispasmodic properties.

Those researches have enabled the WHO and other health agencies (EMA, ESCOP) to validate the positive effects of lemon balm. They have especially brought to light its impact on digestive disorders, such as pain, gastrointestinal spasms and bloating. Furthermore, it helps easing digestion, and boosts the prevention of nausea and vomiting by nurturing bile secretion. Its soothing action also fights against nervous tension and irritability, and facilitates the onset of sleep.

Dandelion : Detoxifiant and Stimulant for the liver

Dandelion is a plant rich in potassium, iron, calcium, copper, silica and manganese. It also contains fatty acids, choline (a nutrient essential to the liver), B-complex vitamins, vitamins C, D and K, as well as flavonoids and carotenoids.
Additionally, its root alone produces insulin and complex sugars, as well as substances that foster the proliferation of beneficial intestinal bacteria (7).

Therefore, Dandelion has always been primarily used to treat liver and gallbladder disorders. It has also been known for its overall “detoxifying” effect, translated into a diuretic action without side effects. Besides, trials conducted in recent years have demonstrated that Dandelion encourages urinary elimination and bile secretion, as well as an anti-inflammatory response. Another study from 2006 confirmed both its properties as an antioxidant and its virtues against cancer and diabetes.

Finally, preliminary clinical trials indicate that some preparations containing Dandelion can relieve intestinal cramps, constipation and diarrhea (8).

Sage : Anti-bloating and digestion stimulant

Sage has been known for ages as an excellent source of vitamin K and iron. It is mainly recommended for its relaxing and antispasmodic action on both the stomach and the intestinal muscles. It is also known for its ability to increase the secretion of bile (9).
Thus, Sage helps easing stomach cramps and protects the gastrointestinal track (heartburn). It is particularly effective against bloating and intestinal gas.
Studies on rodents have shown that Sage significantly stimulates an antioxidant enzyme produced by the liver(10). Besides, it contains two phenolic compounds with proven antioxidant properties – Rosmarinus acid and luteolin.

Sage is highly recommended for the treatment of digestive disorders, including labored digestion, vomiting, bloating and intestinal fermentation. Finally, additional studies have also stressed its ability to improve cognition, reduce agitation for elderly subjects suffering from Alzheimer, and reduce sugar levels in case of mild diabetes.

Four plants combined towards an effective and sustainable effect !

The combination of Fenugreek, Lemon balm, Dandelion and Sage soothes inflammation induced by gastritis, reduces stomach and intestinal spasms, and stimulates the liver. It also helps reaching an internal equilibrium that prevents relapses, especially in case of chronic gastritis.

However, preparing this combination yourself is ill-advised: indeed, while numerous product complexes using dry extracts of these four plants are available on the market, very few are designed with a synergistic action. The synergy formed by the active elements is additional information for the body, since it indicates a time and location for the substances to act – leading to emerging properties without interacting whatsoever! Furthermore, it is crucial to pay attention to the biological qualities, the origin and proportions of the extracts.

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Activa Well Being Gastric is a synergy of 4 plants and amino acids with optimized release of active ingredients using 2 different microgranules for beneficial and targetted effects on the physiological Ph balance of the stomach.

– It consists of Fenugreek containing 20% hydroxyisoleucine.
Combined with a carefully studied combination of sage, dandelion and lemon balm,
– It relieves pain and cramps resulting from gastritis,

– It helps restoring its balance to the gastric mucosa and intestines, and prevents chronic gastritis,
– It stimulates digestion and ensures lasting digestive well-being.
– The active ingredients used are 100% natural, combined in a clever and sequential formulation guaranteeing the synergistic and effective action of the components,
– It is completely bioavailable and biocompatible.
– Resulting from the latest pharmaceutical innovations, the microgranules and their specific release properties ensure a sustained and targeted action of the active ingredients for a maximized efficiency.

Sources:

[1] Pandian RS1, Anuradha CV, Viswanathan P. Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Ethnopharmacol. 2002 Aug;81(3):393-7.
[2] H.M. Helmy. Study the Effect of Fenugreek Seeds on Gastric Ulcer in Experimental Rats. World Journal of Dairy & Food Sciences 6 (2): 152-158, 2011.
[3] Y. Sauvaire, P. Petit, C. Broca, M. Manteghetti, Y. Baissac, J. Fernandez-Alavarez, R. Gross, M. Roye, A. Leconte, R. Gomis, G. Ribes ; 4-hydroxyisoleucine, Diabètes, 1998, 47, 206-210.
[4] Jetté L, Harvey L, Eugeni K, Levens N., 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome, 2009 Apr;10(4):353-8.
[5] Giselle Guginskia, Ana Paula Luizb, Morgana Duarte Silvab, Murilo Massarob, Daniel Fernandes Martinsb, Juliana Chavesa, Robson Willain Mattosc, Damaris Silveirac, Vânia M.M. Ferreirac, João Batista Calixtoa, Adair R.S. Santosa, Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
[6] Mohamed T. Khayyal, Mona A. El-Ghazaly, Sanaa A. Kenawy, Mona Seif-El-Nasr, Laila G. Mahran, Yehia A. H. Kafafi, Samuel N. Okpanyic, Antiulcerogenic Effect of Some Gastrointestinally Acting Plant Extracts and their Combination, Arzneimittelforschung 2001; 51(7): 545-553.
[7] Clare BA, Conroy RS, Spelman K. J Altern, The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. Complement Med. 2009 Aug;15(8):929-34.
[8] Studies cited and summarised in: Kemper Kathi J., MD, MPH. Dandelion (Taraxacum officinalis) The Longwood Herbal Task Force and The Center for Holistic Pediatric Education and Research. www.longwoodherbal.org
[9] Clare BA, Conroy RS, Spelman K. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med. 2009 Aug ;15(8) : 929-34.
10 Lima CF, Andrade PB, Seabra RM et al. The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol. 2005;97:383-389.

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