Galenic form: powder or microgranule?

The rate of release and bioavailability of an active ingredient depending on its galenic formulation may be modified by technological or formulation processes. This is why delayed-release forms are most often tablets or gastro-resistant capsules, releasing the active ingredient into the intestine instead of the stomach.

A capsule naturally contains an active part composed of powder or microgranules. Microgranules were initially associated with a particular function: gastro-resistance, prolonged release, etc. But the latest scientific advances and research on bioavailability have shown a clear preeminence of microgranules over powder in general.

From the moment of manufacture:
– Microgranules are much less sensitive to dust contamination than powder,
– They allow a homogeneous, precise and efficient blend of the active ingredients, which is very difficult to obtain with powder,
– The coating of the microgranule masks the possible taste or smell of the active ingredients and allows them to be consumed “out of capsule”, sublingually,
– Their conservation is excellent, unlike powder which is very sensitive to humidity.

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