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The Synergistic Approach to Immunity & Gut Health: The Power of Pre and Probiotics

The Synergistic Approach
to Immunity & Gut Health:
The Power of Pre and Probiotics

Prebiotics and probiotics complement each other in a synergistic action, fostering a harmonious equilibrium among the diverse bacteria that constitute various microbiotas within the human body. These microbiotas include those found in the mouth, on the skin, in the gut, and the vaginal region.
Prebiotics are indigestible fibers that serve as food for beneficial bacteria in the gut, while probiotics are live microorganisms that provide various health benefits when consumed in adequate amounts. When taken together, prebiotics help nourish and support the growth of probiotics, enhancing their effectiveness in maintaining a healthy balance of the microbiota they compose.
This synergistic combination can help improve the gut or vaginal flora balance, boost immune functions, and promote better digestive health.  

By blending prebiotics with various strains of probiotics, carefully and specifically selected for their benefits, Laboratoires Activa targets precise and optimal results, leveraging their synergistic benefits for effective action.

Activa Symbiotic

12 billion gastro-protected probiotics

  • Strengthens the immune system
  • Restore the intestinal flora after antibiotics, diarrhea, stress
  • Improves bowel motility and uptake of nutrients
  • Specific action of B. Infantis strain on Irritable Bowel Syndrome
  • Improves Lactose tolerance

Activa Symbiotic Digest

Synergy of plants, prebiotics & probiotics

  • Prepares the bolus for a good assimilation in the intestine
  • Limits fermentation, nausea, spasms, and slow digestion-related problems
  • Promotes a good acid-base balance
  • Promotes the microbiota’s development
  • Reduces inflammation & regulates intestinal transit

Activa Symbiotic Gyn

10 billion gastro-protected microbriota

  • Contributes to vaginal PH balance
  • Activates more than 4 times the immunity of the vaginal mucosa
  • Prevents bacterial vaginal infections
  • Proven antifungal action
  • Avoids complications due to antibiotic treatment, proven benefits on vaginal yeast infection
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Nurturing our Future: The Vital Role of Health Supplements for Children

Nurturing our Future:
The Vital Role of Health Supplements for Children

In today’s fast-paced world, where hectic schedules and evolving dietary choices often dominate our lives, ensuring that children receive the essential nutrients they need can be quite a challenge. In this pursuit, the role of health supplements for children has gained increasing attention and significance.

Health supplements for children can help bridge the nutrient gap and ensure they receive all the vital elements they need for optimal growth. While a balanced diet should always be the primary source of nutrients, supplements can serve as a valuable complement, especially in cases where dietary choices are limited or specific nutrient requirements are not being met.

Activa offers a selection of child-safe health supplements designed to enhance both their development and overall well-being:

Activa is dedicated to ensuring the well-being and growth of the next generation. Our carefully crafted health supplements for children serve as a reliable complement to their daily nutrition. We firmly believe that by providing these essential elements, we contribute to the health, vitality, and brighter future of our young ones.

If you are interested to partner with Activa

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Preventing the side effect of antibiotics therapy

Preventing the side effect of antibiotics therapy

Antibiotics are drugs used to fight infections, however, all infections are not treated with antibiotics: antibiotics only work against bacterial infections and are not effective against viral infections such as the common cold or the flu.

When you take antibiotics, they not only kill the harmful bacteria that are causing the infection, but they can also kill some of the beneficial bacteria in your gut.

Taking a probiotic supplement during and after a course of antibiotics can help to restore the balance of bacteria in your gut. This can also help to reduce the risk of antibiotic-associated side effects like diarrhea, vaginal yeast infections, and other digestive problems.

In addition, some studies have suggested that taking probiotics during antibiotic therapy may help to reduce the risk of antibiotic-resistant infections by preventing the overgrowth of harmful bacteria that can become resistant to antibiotics.

It’s important to note, however, that not all probiotics are the same, and different strains of bacteria may have different effects. Laboratoires Activa has developed a range of 3 pre and probiotics blend targeting specific actions and effects in the body.

Diarrhoea

About 1 in 5 person[1] who take antibiotics develop antibiotic-associated diarrhea. Most often, the diarrhea is mild, requires no treatment, and clears up within a few days after you stop taking the antibiotic. However, it is a sign that the balance of the gut microbiome has been affected and taking antibiotic therapy is highly recommended.

Vaginal yeast infections

Yeast infections are common in women who take antibiotics[2]. A lot of antibiotics, which kill some of the bad bacteria, also kill healthy bacteria in your vagina, leading to overgrowth of yeast. Protecting your vaginal flora during and after antibiotic therapy (especially when taking cyclines that promote vaginal yeast infections) will help you avoid having a vaginal yeast infections.

Digestive discomfort

Taking antibiotics can really change the amount and type of bacteria in the gut[3] but also the whole digestive system. These changes in the gut microflora can lead to antibiotic-associated nausea, vomiting and other gastrointestinal side effects.

Sources:
[1]https://www.mayoclinic.org/diseases-conditions/antibiotic-associated-diarrhea/symptoms-cause/syc-20352231#:~:text=About%201%20in%205%20people,you%20stop%20taking%20the%20antibiotic.
[2]https://www.mayoclinic.org/diseases-conditions/yeast-infection/symptoms-causes/syc-20378999#:~:text=Yeast%20infections%20are%20common%20in,leading%20to%20overgrowth%20of%20yeast.
[3]https://www.henryford.com/blog/2020/06/antibiotics-and-probiotics-how-medications-affect-your-gut#:~:text=A%3A%20Taking%20antibiotics%20can%20dramatically,recommend%20taking%20antibiotics%20with%20food.

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Relief and Prevention of Gastritis

Relief and Prevention of Gastritis

Who has never suffered from gastritis? In France, gastritis affects 30% of French adults and 50% of French people over 50! The individuals affected use standard remedies, hence subjected to many relapses.

Gastritis is a chronic inflammation of the gastric mucosa – the membrane lining the stomach. It might be an isolated incident – caused by a bacterium or a virus – but it is mostly chronicle. It creates intense heartburn and digestive disorders.

Gastritis may result either from a frequent autoimmune reaction – induced by Helicobacter pylori (observed in 80% of cases) or from external and chemical aggressions (e.g. consumption of alcohol, tobacco or some medicines). The trigger is not so easily identified, though it appears that stress might often be involved – especially chronic, as a direct or indirect cause.

Cures exist either to help reducing or neutralizing the heartburn, or to support the healing of ulcers. Indeed, antibiotics are commonly used when a Helicobacter pylori infection is diagnosed. Overall, it is recommended to refrain from smoking, drinking alcohol or taking medications which are likely to cause heartburn (as a side effect). Warnings are also valid regarding strict diets.

Alternatives exist for the natural and permanent relief and prevention of gastritis, namely …

Fenugreek : a potent anti-ulcer agent

Fenugreek, (Trigonella foenum graecum) is one of the oldest medicinal plants on Earth. This Mediterranean leguminous plant is highly rich in oligo elements and amino acids. Indeed, it contains phosphorus, iron, Sulphur, nicotinic acid, alkaloids, flavonoids, carbohydrates, vitamins A, B1, and C, magnesium, calcium, lecithin, proteins (30%) and steroidal saponins. Overall, those elements contribute to the synthesis of cholesterol and fibers.

Fenugreek stimulates the appetite and is known for its anti-ulcer properties. Several studies have been conducted to investigate its impact on gastric ulcers (1,2) by comparison with other drugs – such as omeprazole. They showed that Fenugreek seeds exert a potent cryoprotective impact thanks to:

– Its mucilage and galactomannans, which protect the gastric mucosa and functions, and both the small intestine and colon. Indeed, they help soothing gastrointestinal inflammation by forming an efficient protection of the intestinal environment,
– Its quick and powerful inhibitory action upon the secretion of hydrochloric acid (by parietal cells of the stomach),
– Its significant role in the reduction in lipid peroxidation – caused by ethanol – and red cell deterioration by sustaining the activity of antioxidant enzymes (catalase and SOD). Lipid peroxidation plays a major role in the inflammation of the gastric mucosa and the formation of lesions. The mentioned study also highlighted that Fenugreek seeds are more effective than omeprazole as a preventive treatment.

The above elements lead to the conclusion that Fenugreek holds a real anti-ulcer potential.

Besides, Fenugreek acts as a tonic when fatigue kicks in, as a pancreatic stimulant and as an anti-inflammatory. Fenugreek leaves are bitter, hence fortifying the liver and stimulating the production of bile. The latter is more easily expulsed from the gallbladder, thus stimulating the biliary excretion of cholesterol while simultaneously reducing both levels of triglycerides and LDL cholesterol in the blood. Finally, further studies have found out that Fenugreek could also have a preventive effect on the onset of colon, breast and gallbladder cancers.

Fenugreek Hydroxy Isoleucine

Researchers discovered that Fenugreek seeds also contain an unconventional amino acid with highly interesting insulin-stimulant properties (3) – the 4-hydroxyisoleucine. This molecule does not exist either in human or animal cells, and stimulates the secretion of insulin by targeting pancreatic cells. The main interest of hydroxy isoleucine is that it truly differs from sulfonylureas, which are currently used in the treatment of diabetes: indeed, the latter causes hypoglycemic side effects(4), as opposed to 4-hydroxyisoleucine. Nonetheless, it is necessary to specify that only 100% natural Fenugreek extracts provide the efficient quantity of 20% hydroxyisoleucine.

Melissa : Antispasmodic and Choleretic

Melissa (lemon balm) has been famous since the time of ancient Greece for its soothing and digestive properties. It especially helps regulating nerve impulses, hence reducing stomach and colon spasms.
 

Different studies (5,6) have drawn attention on the active substances of lemon balm, such as:
– terpene aldehydes, which have antiviral, calming and sedative properties. They have also antihypertensive, stomachic, antibacterial and anti-inflammatory qualities,

– terpene alcohols, which exert a neurotonic, liver stimulating and immunomodulating effects. They influence emotional and mental states,
– carophyllene contained in sesquiterpenes, which hold has anti-inflammatory, anti-colic and antispasmodic properties.

Those researches have enabled the WHO and other health agencies (EMA, ESCOP) to validate the positive effects of lemon balm. They have especially brought to light its impact on digestive disorders, such as pain, gastrointestinal spasms and bloating. Furthermore, it helps easing digestion, and boosts the prevention of nausea and vomiting by nurturing bile secretion. Its soothing action also fights against nervous tension and irritability, and facilitates the onset of sleep.

Dandelion : Detoxifiant and Stimulant for the liver

Dandelion is a plant rich in potassium, iron, calcium, copper, silica and manganese. It also contains fatty acids, choline (a nutrient essential to the liver), B-complex vitamins, vitamins C, D and K, as well as flavonoids and carotenoids.
Additionally, its root alone produces insulin and complex sugars, as well as substances that foster the proliferation of beneficial intestinal bacteria (7).

Therefore, Dandelion has always been primarily used to treat liver and gallbladder disorders. It has also been known for its overall “detoxifying” effect, translated into a diuretic action without side effects. Besides, trials conducted in recent years have demonstrated that Dandelion encourages urinary elimination and bile secretion, as well as an anti-inflammatory response. Another study from 2006 confirmed both its properties as an antioxidant and its virtues against cancer and diabetes.

Finally, preliminary clinical trials indicate that some preparations containing Dandelion can relieve intestinal cramps, constipation and diarrhea (8).

Sage : Anti-bloating and digestion stimulant

Sage has been known for ages as an excellent source of vitamin K and iron. It is mainly recommended for its relaxing and antispasmodic action on both the stomach and the intestinal muscles. It is also known for its ability to increase the secretion of bile (9).
Thus, Sage helps easing stomach cramps and protects the gastrointestinal track (heartburn). It is particularly effective against bloating and intestinal gas.
Studies on rodents have shown that Sage significantly stimulates an antioxidant enzyme produced by the liver(10). Besides, it contains two phenolic compounds with proven antioxidant properties – Rosmarinus acid and luteolin.

Sage is highly recommended for the treatment of digestive disorders, including labored digestion, vomiting, bloating and intestinal fermentation. Finally, additional studies have also stressed its ability to improve cognition, reduce agitation for elderly subjects suffering from Alzheimer, and reduce sugar levels in case of mild diabetes.

Four plants combined towards an effective and sustainable effect !

The combination of Fenugreek, Lemon balm, Dandelion and Sage soothes inflammation induced by gastritis, reduces stomach and intestinal spasms, and stimulates the liver. It also helps reaching an internal equilibrium that prevents relapses, especially in case of chronic gastritis.

However, preparing this combination yourself is ill-advised: indeed, while numerous product complexes using dry extracts of these four plants are available on the market, very few are designed with a synergistic action. The synergy formed by the active elements is additional information for the body, since it indicates a time and location for the substances to act – leading to emerging properties without interacting whatsoever! Furthermore, it is crucial to pay attention to the biological qualities, the origin and proportions of the extracts.

EN_Activa Academy_Well Being_Gastric_Product Logo.png

Activa Well Being Gastric is a synergy of 4 plants and amino acids with optimized release of active ingredients using 2 different microgranules for beneficial and targetted effects on the physiological Ph balance of the stomach.

– It consists of Fenugreek containing 20% hydroxyisoleucine.
Combined with a carefully studied combination of sage, dandelion and lemon balm,
– It relieves pain and cramps resulting from gastritis,

– It helps restoring its balance to the gastric mucosa and intestines, and prevents chronic gastritis,
– It stimulates digestion and ensures lasting digestive well-being.
– The active ingredients used are 100% natural, combined in a clever and sequential formulation guaranteeing the synergistic and effective action of the components,
– It is completely bioavailable and biocompatible.
– Resulting from the latest pharmaceutical innovations, the microgranules and their specific release properties ensure a sustained and targeted action of the active ingredients for a maximized efficiency.

Sources:

[1] Pandian RS1, Anuradha CV, Viswanathan P. Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Ethnopharmacol. 2002 Aug;81(3):393-7.
[2] H.M. Helmy. Study the Effect of Fenugreek Seeds on Gastric Ulcer in Experimental Rats. World Journal of Dairy & Food Sciences 6 (2): 152-158, 2011.
[3] Y. Sauvaire, P. Petit, C. Broca, M. Manteghetti, Y. Baissac, J. Fernandez-Alavarez, R. Gross, M. Roye, A. Leconte, R. Gomis, G. Ribes ; 4-hydroxyisoleucine, Diabètes, 1998, 47, 206-210.
[4] Jetté L, Harvey L, Eugeni K, Levens N., 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome, 2009 Apr;10(4):353-8.
[5] Giselle Guginskia, Ana Paula Luizb, Morgana Duarte Silvab, Murilo Massarob, Daniel Fernandes Martinsb, Juliana Chavesa, Robson Willain Mattosc, Damaris Silveirac, Vânia M.M. Ferreirac, João Batista Calixtoa, Adair R.S. Santosa, Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
[6] Mohamed T. Khayyal, Mona A. El-Ghazaly, Sanaa A. Kenawy, Mona Seif-El-Nasr, Laila G. Mahran, Yehia A. H. Kafafi, Samuel N. Okpanyic, Antiulcerogenic Effect of Some Gastrointestinally Acting Plant Extracts and their Combination, Arzneimittelforschung 2001; 51(7): 545-553.
[7] Clare BA, Conroy RS, Spelman K. J Altern, The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. Complement Med. 2009 Aug;15(8):929-34.
[8] Studies cited and summarised in: Kemper Kathi J., MD, MPH. Dandelion (Taraxacum officinalis) The Longwood Herbal Task Force and The Center for Holistic Pediatric Education and Research. www.longwoodherbal.org
[9] Clare BA, Conroy RS, Spelman K. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med. 2009 Aug ;15(8) : 929-34.
10 Lima CF, Andrade PB, Seabra RM et al. The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol. 2005;97:383-389.

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Why Prebiotics & Probiotics together?

Why Prebiotics & Probiotics together?

The role of the intestine is not limited to the assimilation of nutrients and the elimination of waste, but it extends to the protection of the whole body. Indeed, it provides an effective preservation against bacteria, viruses, toxic and allergens in the intestinal lumen, through three defensive lines: the intestinal flora, intestinal epithelium, and the intestinal immune system.

Our intestines produce 70 to 85% of the immune cells of the organism and host 100 000 billion bacteria from 400 different species which compose the intestinal flora.

Among these bacteria, most are harmless or beneficial for the body. Under normal circumstances, other, potentially pathogenic, are too few to have an adverse effect. Indeed, by producing lactic acid, the “good” bacteria make the intestinal environment unfavorable to the development of pathogenic bacteria.

The bacteria of the intestinal flora feed on derived food unused by the body (fibers, cartilage, etc.) and play an important role:
– Digestion: The flora completes the food digestion by the fermentation process. It also participates to the digestive motility, in other words, the intestinal transit.
– Assimilation of nutrients.
– Elimination of waste: cholesterol uptake, elimination of toxic as ammonia, nitrites, etc.
– Barrier against infection: the bacteria of the intestinal flora stimulate macrophages and lymphocytes; these cells play a major role in the general immunity of our body.
But, any aggression to the intestinal flora can affect its balance and allow harmful bacteria to grow: stress, overuse of medication, unhealthy diet and/or low in fiber, infections, diseases, or
taking antibiotics.

The enteric nervous system

Studies conducted by Michael D. Gershon, a researcher at Columbia University, US, have shown that the enteric nervous system (intestinal), called also the second brains contains over 100 million neurons and secretes at least 20 neurotransmitters identical to those found in the brain. It participates in the management of our emotions and it is involved in pain control and regulation of thermoregulation, food, and sexual behavior, sleep-wake cycle, pain and anxiety.
In summary, our intestine is a key element for our health and mood. It is, therefore, important to maintain a rich and balanced intestinal flora.

Choose high-quality Probiotics and Prebiotics for a natural, fast and gentle action:

Four Probiotics to restore and balance the intestinal flora

Lactobacillus Rhamnosus
This bacterium has been the subject of considerable research. It is often used in dairy products in Finland and the US, where its virtues to enhance immunity are sought[2]:
– Lactobacillus rhamnosus protects against acute diarrhea[3] caused by viral gastroenteritis.
– Associated to Bifidobacterium longum, it proves a great efficiency to prevent turista – shown by numerous clinical[4] trials

– Associated with Bifidobacterium longum, it acts on the eradication of infections by the helical pylori – this latter being the cause of many gastritis and most peptic ulcers. In 2009, two meta-analyses have proven the effectiveness of probiotics to help cure this infection and mitigate its adverse effects[5,6].
– It improves the condition of people suffering from irritable bowel syndrome by alleviating pain, flatulence, bloating and regulating intestinal[7] transit.
– Lactobacillus rhamnosus reduces the protective layer in the intestines, especially in cases of alcohol[8] problems.
– It avoids complications due to taking an antibiotic[9] treatment.
– It has a powerful action on the vaginal infections, by intervening in the vaginal flora balance[10].
– Lactobacillus rhamnosus has significant impacts on anxiety and obesity by slowing the release of corticotropin-releasing hormones (CRH) that control the activity of the hypothalamic-pituitary-adrena axis[11].

Bifidobacterium Longum
Among the 400 species of bacteria of the intestinal flora, Bifidobacterium longum is one of the most common and most studied. It would constitute more than 95% of the intestinal flora of breastfed[12] infants, which would explain their greater resistance to infection.

Among its actions, it has been verified that:
– Associated with Lactobacillus rhamnosus, she proved great effectiveness to prevent the “turista” (see previous paragraph).
– Associated with Lactobacillus rhamnosus, it acts on the eradication of infections by the helico pylori (see previous paragraph).
– Bifidobacterium longum improves the condition of people suffering from irritable bowel syndrome[13].
– It relieves the symptoms of lactose intolerance[14].
– It calms the inflammation associated with Crohn’s disease or colitis.
– It prevents relapses of ulcerative colitis by extending remissions[15].
– Lactic acid produced by Bifidobacterium longum has anti-carcinogenic and anti-mutagenic properties. Studies have proven its effects on tumor[16].

Lactobacillus Acidophilus
This bacterium was isolated, in 1900, in the faeces of infants and named Bacillus acidophilus because of its remarkable tolerance to acidity.

It has many properties:
– A proven effectiveness in preventing diarrhea caused by antibiotics, in combination with Bifidobacterium longum.
– Lactobacillus acidiphilus specifically attenuates intestinal problems caused by anxiety[17].
– It has been proven it has an antagonistic activity against pathogens of food products such as Staphylococcus aureus, Salmonella typhimurium, Escherichia coli and Clostridium perfringens[18].
– It is known to have the ability to metabolize lactose in the small intestine and thus facilitate its digestion[19].
– It is anti-carcinogenic. An experiment conducted in rats shows a lower incidence of colon cancer after a period of 20 weeks, with the administration of the bacteria[20].
– It easily adheres to the wall of the intestine, which facilitates its implantation in a cure of probiotics[21].
– Finally, Bacillus acidophilus can treat or prevent vaginal infections. In 2009, researchers have compared the effectiveness of various treatments against bacterial vaginosis, one of the most common causes of vaginitis[22]. They concluded that the local use of lactobacilli is more effective than antibiotics prescribed orally (clindamycin, metronidazole).

Bifidobacterium Infantis
This strain of bacteria is acquired naturally during childbirth and then with breastfeeding[23], which would explain the greater resistance to infections in breastfed infants[24].
Irritable bowel syndrome is accompanied by a significant reduction in the amount of intraluminal bifidobacteria, with consequences such as colic gas production and impaired motility of the intestinal tract.
Ingesting a probiotic complement of the Bifidobacterium Infantis strain allows to re-seed good bacteria and to act effectively and without side effects for:
– Reduce pain due to irritable bowel syndrome. Indeed, it has been demonstrated, for example, that a complex of Bifidobacterium Infantis and Longum is associated with better control of intestinal pain and improves quality of life compared to placebo in children with SCI[25]
– Decrease “bloating” which is particularly difficult to treat and often categorized as the most intrusive symptom by those affected by SCI[26],
– Normalize intestinal transit and cause overall relief in patients with SCI,
– Act on the psychological factors of the SCI: Bifidobacterium Infantis is considered as a “psychobiotic”, with anti-inflammatory actions and a real ability to reduce the activity of the hypothalamic-pituitary-adrenal axis which maintains the capacity of the organism to respond to acute and prolonged stressors. Results of large-scale placebo-controlled studies are expected[27]

Two Prebiotics to reinforce the action of the Probiotics

Lactobacillus Acidophilus
This bacterium was isolated, in 1900, in the faeces of infants and named Bacillus acidophilus because of its remarkable tolerance to acidity.

It has many properties:
– A proven effectiveness in preventing diarrhea caused by antibiotics, in combination with Bifidobacterium longum.
– Lactobacillus acidiphilus specifically attenuates intestinal problems caused by anxiety[17].
– It has been proven it has an antagonistic activity against pathogens of food products such as Staphylococcus aureus, Salmonella typhimurium, Escherichia coli and Clostridium perfringens[18].
– It is known to have the ability to metabolize lactose in the small intestine and thus facilitate its digestion[19].
– It is anti-carcinogenic. An experiment conducted in rats shows a lower incidence of colon cancer after a period of 20 weeks, with the administration of the bacteria[20].
– It easily adheres to the wall of the intestine, which facilitates its implantation in a cure of probiotics[21].
– Finally, Bacillus acidophilus can treat or prevent vaginal infections. In 2009, researchers have compared the effectiveness of various treatments against bacterial vaginosis, one of the most common causes of vaginitis[22]. They concluded that the local use of lactobacilli is more effective than antibiotics prescribed orally (clindamycin, metronidazole).

Ribose
Ribose is a sugar useful to all living organisms. It plays three major roles:
– It is a component of adenosine triphosphate (ATP), the fuel of cell that meets the body’s energy needs.
– It has an action on the UTP (Uridine triphosphate): a compound that provides energy, helps the muscle recovery and promotes the synthesis of glycogen.
– It enables the production of ribonucleic acid (RNA) for the transcription of the genetic[33] code.

Ribose is therefore particularly important to stimulate all the body and reinforce the bacteria in the intestinal flora.
– It is composed of a studied mixture of three different Probiotics for further action and a full and rapid colonization of the intestine,
– To these Probiotics are associated two Prebiotics to reinforce their action, this complex contains strains recognized for their effectiveness and their complementary action,
– It reinforces the immune system,
– It improves the transit
– It restores the intestinal flora,
– It reduces the recurrence of vaginal mycoses,
– It helps to prevent the “turista” 15 days to 1 month before the trip,
– It avoids the undesirable effects of a long antibiotic therapy,
– The excellent tolerance achieved through the synergy of these components allows being used in the long term without side effects,
– It works by “Sustained release” to pass the gastric barrier,
– It is made from 100% natural active, with a “smart” formulation for a synergistic and effective action of the components,
– It is completely bioavailable,
Biocompatible, it respects the body and acts in depth on our vitality.

Sources:

[1] Haddad PS, Azar GA, et al. Natural health products, modulation of immune function and prevention of chronic diseases. Evid Based Complement Alternat Med. 2005 Dec;2(4):513-20. Full text: http://ecam.oxfordjournals.org
[2]  Doctissimo.fr website accessed September 11, 2014 « Il y a probiotiques et probiotiques »
[3] Szajewska H, Mrukowicz JZ. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr. 2001 Oct;33 Suppl 2:S17-25.
[4] McFarland LV. Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Med Infect Dis. 2007 Mar;5(2):97-105. Epub 2005 Dec 5.
[5] Sachdeva A, Nagpal J. Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials. Eur J Gastroenterol Hepatol. 2009 Jan;21(1):45-53.
[6] Zou J, Dong J, Yu X. Meta-analysis: Lactobacillus containing quadruple t! herapy versus standard triple first-line therapy for Helicobacter pylori eradication. Helicobacter. 2009 Oct;14(5):97-107.
[7] Nikfar S, Rahimi R, et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Dis Colon Rectum. 2008 Dec;51(12):1775-80. Epub 2008 May 9.
[8] Wang, Y.; Liu, Y.; Sidhu, A.; Ma, Z.; McClain, C.; Feng, W. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury. Am J Physiol Gastrointest Liver Physiol 303 (1): G32–41. doi:10.1152/ajpgi.00024.2012. PMID 22538402. Forsyth, CB.; Farhadi, A.; Jakate, SM.; Tang, Y.; Shaikh, M.; Keshavarzian, A. (Mar 2009). Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 43 (2): 163–72. doi:10.1016/j.alcohol.2008.12.009. PMID 19251117.
[9] McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006 Apr;101(4):812-22. http://www.ncbi.nlm.nih.gov/pubmed/16635227
[10] Oduyebo OO, Anorlu RI, Ogunsola FT. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD006055. Revi! ew. http://www.ncbi.nlm.nih.gov/pubmed/19588379
[11] Alison C Bested, Alan C Logan, Eva M Selhub. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials. Gut Pathog. 2013; 5: 4. Published online 2013 March 16. doi: 10.1186/1757-4749-5-4 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605358/
[12] Yoshioka H. et al., Development of the normal intestinal flora and its clinical significance in infants and children, Bifidobacteria and Microflora, 1991, 10(1): 11-17.
[13] Nikfar S, Rahimi R, et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Dis Colon Rectum. 2008 Dec;51(12):1775-80. Epub 2008 May 9.
[14] He T1, Priebe MG, Zhong Y, Huang C, Harmsen HJ, Raangs GC, Antoine JM, Welling GW, Vonk RJ. Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. J Appl Microbiol. 2008 Feb;104(2):595-604. Epub 2007 Oct 9. http://www.ncbi.nlm.nih.gov/pubmed/17927751.
[15] Sang LX, Chang B, et al. Remission induction and maintenance effect of probiotics on ulcerative colitis: a meta-analysis. World JGastroenterol. 2010 Apr 21;16(15):1908-15. http://www.ncbi.nlm.nih.gov/pubmed/20397271
[16] Benno, Y.; Mitsuoka, T. (1992). Impact of Bifidobacterium longum on human fecal microflora. Microbiology and immunology 36 (7): 683–694
[17] Diop L, Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial, Nutr Res. 2008 Jan;28(1):1-5. doi: 10.1016/j.nutres.2007.10.001
[18] M.E. Sanders, Invited Review: The Scientific Basis of Lactobacillus acidophilus NCFM Functionality as a Probiotic, Journal of Dairy Science, vol. 84, no 2,‎ 2001-02, p. 319-331 ISSN 0022-0302, DOI 10.3168/jds.S0022-0302(01)74481-5
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[23] Mark A. Underwood, J. Bruce German, Carlito B. Lebrilla, David A. Mills. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatr Res. Author manuscript; available in PMC 2015 March 5. Étude ici
[24] Yoshioka H. et al., Development of the normal intestinal flora and its clinical significance in infants and children, Bifidobacteria and Microflora, 1991, 10(1): 11-17.

[25] https://www.ncbi.nlm.nih.gov/pubmed/27306945
[26] Nikfar 171

[27] https://www.ncbi.nlm.nih.gov/pubmed/23759244
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B. Infantis, the forgotten but essential probiotic strain

B. Infantis, the forgotten
but essential probiotic strain

The microbiome plays an essential role in our immunity. We are born with a “capital” that is directly linked to the one of our mother, as our first exposure to external pathogens is in the womb, and colonization of the baby microbiome happens at birth soon as the water bag breaks, and natural delivery allows the baby to come in contact with the mother’s microbiome to seed its own.

Children born through c-section may lack exposure to some beneficial microbiota strains
(probiotics) which are essential support for digestive health and building strong immunity.

The Bifidobacterium infantis strain of bacteria is one of them. Like the Bifidobacterium Longum, it is a probiotic acquired naturally during childbirth and then with breastfeeding(1). This would explain the greater resistance to infection in breastfed children(2).

From the same family as Longum, its high nicotinic and folic acid content makes it specific. A theory called “hygiene hypothesis”(3) demonstrates that the increase, in many developed countries, of atopic allergic diseases (such as asthma, dermatitis or rhinitis) is due to the absence of an early exposure to Bifidobacterium Infantis.

Numerous scientific studies support this theory and have shown that breastfeeding and the environmental conditions in which babies are born and fed can influence the composition of their intestinal flora(4).

This intake (or lack) of probiotics, including Bifidobacterium Infantis, can alter the initial regulation of the developing immune system and then influence the intestinal balance and digestive health of an individual throughout their life.

In addition, Bifidobacterium Infantis is particularly recommended for reducing symptoms of IBS – Irritable Bowel Syndrome – in women. According to a study sponsored by the P&G Health Sciences Institute and published in the American Journal of Gastroenterology, this strain is effective in relieving bloating, bowel problems and pain(5).

Sources:
[1] Mark A. Underwood, J. Bruce German, Carlito B. Lebrilla, David A. Mills. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatr Res. Author manuscript; available in PMC 2015 March 5. Study here
[2] Yoshioka H. et al., Development of the normal intestinal flora and its clinical significance in infants and children, Bifidobacteria and Microflora, 1991, 10(1): 11-17.
[3] Hypothèse de l’hygiène Professeur Pierre MASSON Institut Christian de Duve – Université Catholique de Louvain
[4] Sarah L. Young, Mary A. Simon, Margaret A. Baird, Gerald W. Tannock, Rodrigo Bibiloni, Kate Spencely, Juliette M. Lane, Penny Fitzharris, Julian Crane, Ian Town, Emmanuel Addo-Yobo, Clare S. Murray and Ashley Woodcock. Bifidobacterial Species Differentially Affect Expression of Cell Surface Markers and Cytokines of Dendritic Cells Harvested from Cord Blood. Clin Diagn Lab Immunol. 2004 Jul; 11(4): 686–690. doi: 10.1128/CDLI.11.4.686-690.2004. PMCID: PMC440611
[5] Whorwell PJ 1, Altringer L , Morel J , Bond Y , Charbonneau D , O’Mahony L , Kiely B , Shanahan F , Quigley EM . Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol. 2006 Jul;101(7):1581-90.
[6] https://www.ncbi.nlm.nih.gov/pubmed/27306945
[7] Nikfar 171
[8] https://www.ncbi.nlm.nih.gov/pubmed/23759244

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