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Activa Omega 3 Supplements: The innovation that makes the difference

Activa Omega 3 Supplements
– The innovation that makes the difference –
High bioavailability, purity and reduced dosage

Omega-3 fatty acids are essential nutrients that are important for overall health and wellness. They offer great health benefits, including reducing inflammation, improving heart health, and supporting brain function. There are two main forms of omega-3 fatty acids that are commonly found in fish oil based supplements: Ethyl Ester (EE) and Triglyceride (TG) forms.

The primary difference between omega-3 EE and TG forms lies in The chemical structure of their nucleus. 

In the EE form, the nucleus is chemically modified to create an ethyl ester, which allows to enrich it with EPA/DHA in the required proportions and purify them. Unfortunately the downside is that they have a low availability and oxidise fasts.

In contrast, the TG form is the natural form of omega 3, this is how it is found in fish and this is how we store and use it in our bodies. Its bioavailability is excellent. However, natural fish oils are not very concentrated in EPA/DHA and they contain impurities.
As a consequence; to have the right dose of fatty acids, it is necessary to take a large dose of oil (and its impurities), which can affect digestion and intestinal transit.

A solution is to transform these TG oils into EE, this process is called transesterification. To put it simply, EPA/DHA is separated from its glycerol support, purified and recombined with an alcohol (ethanol). Through this chemical manipulation, we obtain purified fatty acids that can be concentrated in EPA/ DHA as desired.

However, an important downside is that EE oil oxidises more quickly. Moreover, as this is a new form that does not exist in nature, our body has, unfortunately, high difficulty assimilating it as it doesn’t have the enzymes necessary to separate EPA and DHA from its ethanol support. Some studies show that the absorption of a TG vs EE oil ranges from 71% to 400%…

Another option, which is costly because it involves a long and complicated process, is to take the EE oil and separate it from its ethanol support, and recombine it in TG form by adding glycerol.
As a result, we have the best of both worlds: a purified oil with a high concentration of EPA DHA .
Moreover, this oil has also a better resistance to oxidation thanks to a specific airless encapsulating method.
It means that thanks to this specific transformation process, this oil is highly concentrated in EPA and DHA, and because it has a low oxidation, you can ingest small doses (in the form of small soft gel capsules (while most products are hard and large capsules), achieve a high bioavailability and enjoy its health benefits.

How do you know if your oil is in TG or EE oil?

If TG is indicated on the packaging, it means that it is in the triglyceride form, however if it is not indicated the oil is an EE form.

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EPA and DHA in Omega 3, what do they do?

EPA and DHA in Omega 3, what do they do?

The EPA & DHA are “anti-platelet aggregation”

When blood platelets stick together, they can form arterial plugs (thromboses) that prevent blood from flowing. This blood clot can detach and block a small vessel in the brain, resulting in a transient ischemic stroke. Omega 3 promote the production of nitric oxide which protects blood vessels.

Moreover, EPA and DHA are anti-atherogenic since they fight against the formation of fatty deposits(1).

Indeed, EPA inhibits the synthesis of thromboxane – prostaglandin promoting platelet adherence – and on the other hand, stimulates the production of prostacyclins that decrease platelet aggregation.

DHA & EPA help fight against oxidative stress

We know that oxidative stress plays a role in the formation of clots. By incorporating itself into the platelets’ membrane, EPA protects them against free radicals and thus reduces their aggregation. A 3-year study of 563 men with hyperlipidemia showed that supplementation with Omega 3 reduced the concentration of platelet adhesion molecules, thereby reducing the risk of atherosclerosis and stroke (2).

Moreover, in chronic heart failure (CHF), cardiomyocytes are disorganized and free radicals are produced in excess, exceeding the neutralizing capacities of enzymatic equipment. Daily supplementation with Omega-3 significantly increases the concentration of superoxide dismutase (SOD), a key enzyme in the fight against free radicals (3).

In conclusion, through a set of complex mechanisms, not yet fully clear, Omega 3 reduces triglyceridemia, platelet aggregation and regulate heart rate and contractility, thus protecting against cardiovascular risk.

Impact of DHA & EPA on the heart from childhood

Several studies have shown the relationship between blood DHA levels and blood pressure in healthy children. Children who are breastfed, either by breast milk or by milk supplemented with Omega 3 have a lower blood pressure at the age of 6-7 years(4). More generally, the needs of a child between 3 and 9 years are 250 mg EPA + DHA and rise to 500 mg between 10 and 18 years, but the levels of these two omega-3 fatty acids are too low in the Western diet. Supplementation with DHA and EPA during pregnancy, lactation and childhood, therefore, plays an important role in cardiovascular development and function(5).

What are optimum needs in DHA & EPA?

Although omega-3s have many virtues for the human body, they are still insufficiently consumed today, since our diet provides us with only 30% of the DRI (Dietary Reference Intakes).

After evaluating the French population’s daily intake of omega-3, the ANSES recommended: “the implementation of a policy aimed at increasing the level of omega-3 intake” (6).

The minimum physiological requirement for DHA and EPA was estimated by the ANSES to be 500 mg/day for an adult. Adults in France receive an average of 350mg of EPA + DHA per day for women and 420 mg/day for men (7). They are therefore below the 500 mg/day guideline. Supplementation of about 100 mg minimum is essential for good memory and optimal brain function.

Activa Human Structure Cardio,
quality Omega 3 to support the cardiovascular sphere

 

Sources:

[1] O’Keefe JH Jr & Harris WS: From Inuit to implantation : omega-3 fatty acids come of age. Mayo Clin. Proc. 2000 Jun;75(6):607-14.
[2] Smith BK. & Al.: Exercise plus n-3 fatty acids: additive effect on postprandial lipemia. Metabolism. 2004 Oct;53(10):1365-71.
[3] Mori TA & Woodman RJ: The independant effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovasclar risk factors in humas.2006 Mar;9(2):95-104.
[4] Hjerkinn EM & Al.: Influence of long term intervention with dietary counseling, long chain n-3 fatty acid supplements, or both on circulation markers of endothelial activation in men with long-standing hyperlipidemia. Am. J. Nutr. 2005 Mar;81(3):583-9.
[5] Luostarinen, 1997
[6] Oméga-3. Afssa Février 2009 – www.afssa.fr
[7] EFSA. Scientific opinion – Labelling reference intake values for n-3 and n-6 polyunsaturated fatty acids. The EFSA Journal 1176, 1-11, 2009
Forsyth JS, Willatts P, Agostoni C, Bissenden J, Casaer P, Boehm G. Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later
childhood: follow up of a randomised controlled trial. Br Med J. 2003;326:953.
Koletzko B. Fats for brains. Eur J Clin Nutr 1992 ; 46 Suppl 1: S51-62.

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3 Essential Criteria for the Best Omega 3

3 Essential Criteria
for the Best Omega 3

Although omega-3s have many virtues for the human body, they are still insufficiently consumed today, since our diet provides us with only 30% of the DRI (Dietary Reference Intakes).
Supplementation is thus essential. Some important criteria are to consider when choosing them as they can make a big difference in benefits.

The benefits of EPA and DHA

When blood platelets stick together, they can form arterial plugs (thromboses) that prevent blood from flowing. This blood clot can detach and block a small vessel in the brain, resulting in a transient ischemic stroke. Omega 3 promotes the production of nitric oxide which protects blood vessels.

Moreover, EPA and DHA are anti-atherogenic since they fight against the formation of fatty acids in the arteries..

Indeed, EPA inhibits the synthesis of thromboxane – a hormone promoting platelet adherence and arterial construction – and on the other hand, stimulates the production of prostacyclins that decrease platelet aggregation.

Why are EPA and DHA so efficient for our health?

What are our optimum needs in DHA and EPA?

After evaluating the French population’s daily intake of omega-3, the ANSES recommended: “The implementation of a policy aimed at increasing the level of omega-3 intake” (9).

The minimum physiological requirement for DHA and EPA was estimated by the ANSES to be 500 mg/day for an adult.
Supplementation of about 100 mg minimum is also essential for good memory and optimal brain function.

 

The EPAX® label,
a gauge of quality in fish oil source

Epax® is a world-leading brand of concentrated omega 3 fatty acids based on three main principles:

  • PURITYUltra-pure oil that sets industry purity standards
    Epax is committed to producing ultra-pure omega-3 ingredients that are safe for ongoing human use.
  • QUALITY Ongoing supply of highest-quality traceable ingredients from a sustainable source
    For all Epax ingredients, Epax ensures quality control at every stage from the sourcing of the crude oil to finished omega-3 concentrates and applies strict traceable ethical practices.
  • INNOVATIONIndustry leaders in technology, manufacturing, and product development
    As a leading brand in the field of omega-3s, Epax has a long history of “firsts” that have raised industry standards. Epax is committed to the ongoing development of new omega-3 products, high-tech manufacturing solutions for the omega-3 category, and new marketing opportunities for Epax customers.

The encapsulation process

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